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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Toxicology. 2023 Nov 22;500:153677. doi: 10.1016/j.tox.2023.153677

Fig. 5.

Fig. 5.

Subacute exposure to 4-52 via polymeric implants containing 0 (sham), 1, 5, or 10% of 4-52 did not alter (A) 5 min center zone entries of day 1, (B) 5 min center zone entries of day 2, (C) time in the center zone during the first 5 min on day 1, (D) time in the center zone during the first 5 min on day 2, (E) travel distance in the center zone during the first 5 min on day 1, (F) travel distance in the center zone during the first 5 min on day 2, (I) total distance on day1, and (J) total distance on day 2 in the Open Field Test. The travel distance was also not altered by 4-52 exposure over time, illustrated in 5 min epochs for 30 min on (G) day 1 and (H) day 2 of the Open Field Test. Data are expressed as mean ± standard deviation with individual dots representing different animals (n=15). Statistical differences were compared by one-way analysis of variance (ANOVA) using Fisher’s LSD test for multiple comparisons. Two-way ANOVA was used to compare the distance traveled over 5-minute intervals.