Table 2.
Descriptive characteristics at baseline of the participants from the COMETS cohorts containing incident and/or prevalent myocardial infarction data
| Cohort (Metabolite number) | MI type | Subsets | Sample Size, N | Women, % | Baseline Age, years | Follow-up Age, years | BMI, kg/m2 | Race, % | Follow-up Time, years |
|---|---|---|---|---|---|---|---|---|---|
| ARIC (n = 311) | Incident | All participants | 3776 | 61 | 53 (5.7) | 76 (8.7) | 28.8 (5.9) | 38% White, 62% Black | 22.8 (8.4) |
| MI cases | 442 | 55 | 55 (5.7) | 70 (9) | 29.3 (5.4) | 41% White, 59% Black | 15.5 (8) | ||
| Controls | 3334 | 62 | 53 (5.7) | 77 (8.3) | 28.7 (5.9) | 38% White, 62% Black | 23.8 (7.8) | ||
| Prevalent | All participants | 3395 | 62 | 53 (5.8) | – | 28.7 (5.9) | 38% White, 62% Black | – | |
| MI cases | 54 | 33 | 57 (5.7) | – | 29.1 (5.1) | 56% White, 44% Black | – | ||
| Controls | 3341 | 62 | 53 (5.7) | – | 28.7 (5.9) | 38% White, 62% Black | – | ||
| ET2DS (n = 208) | Incident | All participants | 909 | 53 | 68 (4.2) | 77 (4.6) | 31.4 (5.8) | 98% White, 2% non-Whiteb | 9.5 (2.8) |
| MI cases | 66 | 47 | 69 (3.8) | 75 (4.9) | 31.2 (5.4) | 98% White, 2% non-Whiteb | 5.9 (3.1) | ||
| Controls | 843 | 53 | 68 (4.2) | 77 (4.6) | 31.4 (5.8) | 98% White, 2% non-Whiteb | 9.8 (2.6) | ||
| Prevalent | All participants | 992 | 49 | 68 (4.2) | – | 31.4 (5.7) | 98% White, 2% non-Whiteb | – | |
| MI Cases | 147 | 22 | 69 (4.1) | – | 31.3 (5.2) | 98% White, 2% non-Whiteb | – | ||
| Controls | 845 | 53 | 68 (4.2) | – | 31.5 (5.8) | 98% White, 2% non-Whiteb | – | ||
| GDM (n = 210) | Incident | All participants | 477 | 41 | 69 (9.3) | 73 (9.1) | 30.3 (5.2) | 100% White | 4.4 (1.3) |
| MI cases | 42 | 33 | 70 (8.4) | 73 (8.2) | 30.1 (5.3) | 100% White | 2.3 (1.6) | ||
| Controls | 435 | 42 | 69 (9.4) | 74 (9.2) | 30.4 (5.2) | 100% White | 4.5 (1.2) | ||
| Prevalent | All participants | 468 | 41 | 69 (9.4) | – | 30.4 (5.2) | 100% White | – | |
| MI cases | 33 | 33 | 71 (10.1) | – | 31.5 (4.8) | 100% White | – | ||
| Controls | 435 | 42 | 69 (9.4) | – | 30.4 (5.2) | 100% White | – | ||
| HABC (n = 350) | Incident | All participants | 236 | 0 | 75 (2.8) | 83 (4.7) | 27.0 (4.5) | 100% Black | 10.6 (5) |
| MI cases | 25 | 0 | 75 (2.8) | 83 (4.7) | 27.0 (4.6) | 100% Black | 7.6 (3.7) | ||
| Controls | 211 | 0 | 75 (2.9) | 81 (4.4) | 26.8 (3.2) | 100% Black | 10.6 (5.1) | ||
| Prevalent | All participants | 1764 | 0 | 75 (2.8) | – | 27.0 (4.5) | 100% Black | – | |
| MI cases | 63 | 0 | 75 (2.8) | – | 27.6 (4.6) | 100% Black | – | ||
| Controls | 1701 | 0 | 74 (2.8) | – | 26.8 (4.4) | 100% Black | – | ||
| TwinsUK (n = 591) | Incident | All participants | 911 | 97 | 65 (8) | 70 (7.7) | 26.1 (4.8) | 100% White | 3.9 (2.9) |
| MI cases | 5 | 80 | 74 (5.2) | 77 (5.2) | 31.7 (9.6) | 100% White | 2.6 (0.1) | ||
| Controls | 906 | 97 | 66 (8) | 70 (7.7) | 26.1 (4.7) | 100% White | 3.9 (2.9) | ||
| Prevalent | All participants | 1708 | 97 | 65 (8.6) | – | 26.3 (4.8) | 100% White | – | |
| MI cases | 13 | 77 | 71 (5.8) | – | 28.5 (5.8) | 100% White | – | ||
| Controls | 1695 | 97 | 65 (8.6) | – | 26.3 (4.8) | 100% White | – | ||
| WHI (n = 414) | Incident | All Participants | 1588 | 100 | 67 (6.9) | 72 (7.5) | 28.4 (6.1) | 77% White, 23% non-Whitea | 5.1 (3.3) |
| MI cases | 793 | 100 | 67 (7.0) | 72 (7.5) | 29.0 (6.3) | 77% White, 23% non-Whitea | 5.1 (3.3) | ||
| Controls | 795 | 100 | 67 (6.9) | 72 (7.4) | 27.9 (5.9) | 77% White, 23% non-Whitea | 5.1 (3.3) | ||
| KORA (n = 353) | Prevalent | All participants | 1765 | 52 | 61 (8.8) | – | 28.2 (4.8) | 100% White | – |
| MI cases | 63 | 22 | 67 (6.6) | – | 30.7 (5.1) | 100% White | – | ||
| Controls | 1702 | 53 | 61 (8.8) | – | 28.1 (4.8) | 100% White | – | ||
| Total (unique: n = 1428) | Incident | All participants | 7897 | 59 | 66 (7.1) | 75 (4.6) | 28.7 (2) | 69% White, 29% Black, 2% Others | 9.4 (7.1) |
| MI cases | 1373 | 53 | 68 (7.3) | 75 (4.6) | 29.7 (1.7) | 69% White, 29% Black, 2% Others | 6.5 (4.8) | ||
| Controls | 6524 | 59 | 66 (7.2) | 75 (4) | 28.6 (2.1) | 69% White, 29% Black, 2% Others | 9.6 (7.5) | ||
| Prevalent | All participants | 10 092 | 50 | 65 (7.4) | – | 28.7 (2) | 73% White, 27% Blackc | – | |
| MI cases | 373 | 31 | 68 (6) | – | 29.8 (1.6) | 76% White, 24% Blackc | – | ||
| Controls | 9719 | 51 | 65 (7.2) | – | 28.6 (2) | 73% White, 27% Blackc | – |
aIn the WHI, non-White included: 14% Black or African-American, 3% Hispanic/Latino, 2% Asian or Pacific Islander, and 4% others.
bIn the ET2DS, non-White included for prevalent: 1.1% Asian, 0.2% Black, 0.1% White and Black Caribbean, and 0.1% White and Asian. Specifically, 98.4% are White. Non-White included for incident: 1.1% Asian, 0.2% Black, 0.1% White and Black Caribbean, and 0.1% White and Asian. Specifically, 98.5% are White.
cIt presents <1% of other ethnicities (non-White and non-Black).