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. 2023 Sep 23;119(17):2729–2742. doi: 10.1093/cvr/cvad153

Figure 5.

Figure 5

Age dependency of circulating GDF11/MSTN and their predictive value for the estimation of final infarct size in patients with acute myocardial infarction. (A, B) LC/LC-MS-based quantification of plasma GDF11 and MSTN per age quintile (n = 20/quintile; left) and Spearman rank correlation between continuous GDF11 and MSTN, respectively, with age (right). Simple linear regression and 95% confidence bands of the best fit line is plotted. (C) Unstandardized coefficients (B) of each independent variable included in the final regression model (model 3) ranked by their importance for the prediction of standardized peak CK-MB levels, a surrogate of final infarct size. Line length corresponds with the 95% CI. P values were calculated by one-way ANOVA [A (left), B (left), C] or Spearman rank correlation [A (right), B (right)], with Spearman’s ρ along with its 95% CI noted in the respective panel of A and B, respectively. Data in A and B (left panels) are presented as bar graphs with error bars (mean and SEM) with single data points superimposed.