TABLE 3.
Ten most downregulated protein coding genes in NTRK2–/– ReNcell VM.
| Gene | Log2FC | Adjusted p-value | Brain specificity | Enriched brain cell expression (adult) |
| MAGEH1 | −10.84 | 1.60804E-08 | No | Neurons, oligo, OPC |
| MGMT | −10.68 | 4.15432E-06 | No (hepatocytes) | Neurons, oligo, OPC, astrocytes |
| EBF2 | −10.43 | 1.48106E-07 | No | Microglia |
| CMBL | −10.02 | 4.03068E-06 | No (enterocytes) | Neurons |
| LHX5 | −9.25 | 0.000236301 | No | None |
| NEUROD4 | −9.04 | 3.0599E-07 | Yes | Neurons |
| NRN1 | −9.03 | 1.48106E-07 | No (adipocytes) | Neurons |
| NLRP2 | −8.64 | 7.25049E-07 | No | Neurons |
| NHLH2 | −8.63 | 1.07925E-06 | No (skeletal muscle) | Neurons, oligo, OPC |
| MGST2 | −8.00 | 2.56506E-05 | No (liver) | Neurons, microglia |
Oligo, oligodendrocytes; OPC, oligodendrocyte progenitor cells.