Extended Data Figure 1:

a. Representative immunohistochemistry images and quantification of Ki67 staining in pancreas tissue of vehicle and cerulein treated mice as in a; n=4 mice/group, *P=0.0079. b. Flow cytometry plots of gating strategy used for pancreas F4/80⁺MHCII^hi/lo macrophages. c. Density of F4/80^loMHCII⁻ eosinophils, Ly6G⁺ granulocytes, and Ly6C⁺ monocytes in pancreas of mice treated with vehicle or cerulein by 6 hourly i.p. injections every other day for one week; n=4 mice/group, *P=0.0286 for eosinophil analysis, *P=0.0286 for granulocyte analysis, and *P=0.0286 for monocyte analysis. Data are presented as mean ± SEM unless otherwise indicated. n.s., not significant; *p <0.05. For comparisons between two groups, Student’s two-tailed t-test was used.