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. Author manuscript; available in PMC: 2023 Dec 31.
Published in final edited form as: ACM BCB. 2023 Oct 4;2023:8. doi: 10.1145/3584371.3612968

Table 5:

Select significant block modules extracted through Dual ICA using the M. tuberculosis dataset

Module Conditions Genes (total) Significant KEGG Pathways
C0 x G42+

  • MeanLFC = +1.53,

  • Regression Coeff. = +0.54

  • Wald Test p-value = 0

 Dipyridyl (ironLimitatlon) IronDefident_Day1 (Fortune) mbtABCDEFGHIJ, PPE37,… (120)

  • Biosynthesis of siderophore group nonribosomal peptides (ES=4.566 qval=0.002)

  • Polyketide biosynthesis proteins (ES=4.219 qval=0.002)

  • Metabolism of terpenoids and polyketides (ES=3.198. qval=0.009)
Clofazimine (respiration) IronDeficient_Week1 (Fortune)
Deferoxamine (ironLimitatlon) 1_days_low_iron (stress)
GSNO_CFZ (respiration) 7_days_low_iron (stress)
Ascididemin_Nat_prod (ironLimitation)
C25− x G10+

  • MeanLFC = +1.35,

  • Regression Coeff. = −0.49

  • Wald Test p-value = 0

 Levo (DNAdamaging) rvuABC, dnaAB, lexA, recAX, alkA,… (177)

  • Base excision repair (ES 3.265 qval=0.012)

  • DNA repair and recombination proteins (ES=6.834 qval=0.004)

  • DNA replication (ES=3.673 qval=0.004)

  • DNA replication proteins (ES=3.462 qval=0.005)

  • Homologous recombination (ES=4.887 qval=1.39E-05)

  • Mismatch repair (ES= 4.082 qval=0.001)

  • Nucleotide excision repair (ES=3.478 qval=0.008)

  • Protein families: genetic Information processing (ES=2.964 qval=5.32E-09)

  • Replication and repair (ES=6.761 qval=3.89E-13)

  • Unclassified: genetic Information processing (ES=3.235 qval=0.004)
Novobiocin (DNAdamaging)
Oflox (DNAdamaging)
UV (DNAdamaging)
mcr11_mutant (mcr11)