TABLE 1.
Baseline characteristics and laboratory results in patients with good and poor outcomes at 3 months.
| Variable | All patients (n = 591) | Good outcome (n = 444) | Poor outcome (n = 147) | p Value |
|---|---|---|---|---|
| Characteristics | ||||
| Age (median [IQR]) | 68.00 [61.00, 79.00] | 66.00 [59.00, 74.00] | 80.00 [67.00, 86.00] | <.001* |
| Gender (male), N (%) | 351 (59.4) | 280 (63.1) | 71 (48.3) | .002* |
| Stroke severity, N (%) | <.001* | |||
| NIHSS score (0–4) | 272 (46.0) | 253 (57.0) | 19 (12.9) | |
| NIHSS score (5–15) | 252 (42.6) | 172 (38.7) | 80 (54.4) | |
| NHISS score (16–20) | 42 (7.1) | 14 (3.2) | 28 (19.0) | |
| NIHSS score (21–42) | 25 (4.2) | 5 (1.1) | 20 (13.6) | |
| Subgroup of TOAST, N (%) | <.001* | |||
| Small‐artery occlusion | 238 (40.3) | 216 (48.6) | 22 (15.0) | |
| Large‐artery atherosclerosis | 166 (28.1) | 127 (28.6) | 39 (26.5) | |
| Cardio‐embolism | 140 (23.7) | 70 (15.8) | 70 (47.6) | |
| Undetermined etiology | 36 (6.1) | 23 (5.2) | 13 (8.8) | |
| Other etiology | 11 (1.9) | 8 (1.8) | 3 (2.0) | |
| Infarct location, n (%) | .446 | |||
| Anterior circulation | 459 (77.7) | 341 (76.8) | 118 (80.3) | |
| Posterior circulation | 132 (22.3) | 103 (23.2) | 29 (19.7) | |
| DNT, min (median [IQR]) | 47.0 [34.0, 70.0] | 46.0 [34.0, 70.0] | 49.0 [33.5, 71.0] | .568 |
| OTT, min (median [IQR]) | 132.0 [96.0, 175.0] | 133.0 [98.0, 180.0] | 128.0 [87.5, 165.0] | .087 |
| Hypertension, N (%) | 415 (70.2) | 303 (68.2) | 112 (76.2) | .085 |
| Diabetes, N (%) | 153 (25.9) | 107 (24.1) | 46 (31.3) | .106 |
| Smoking, N (%) | 247 (41.8) | 206 (46.4) | 41 (27.9) | <.001* |
| Drinking, N (%) | 105 (17.8) | 84 (18.9) | 21 (14.3) | .250 |
| AF, N (%) | 127 (21.5) | 61 (13.7) | 66 (44.9) | <.001* |
| Prior stroke or TIA, N (%) | 90 (15.2) | 60 (13.5) | 30 (20.4) | .060 |
| Laboratory results | ||||
| Hs‐CRP, mg/L (median [IQR]) | 3.00 [1.60, 5.37] | 3.00 [1.60, 5.00] | 3.00 [1.60, 7.90] | .020* |
| FBG, mmol/L (median [IQR]) | 6.90 [6.00, 8.80] | 6.80 [5.90, 8.40] | 7.30 [6.20, 10.30] | .023* |
| Hba1c (%) (median [IQR]) | 5.90 [5.60, 6.60] | 5.90 [5.60, 6.60] | 5.90 [5.60, 6.85] | .290 |
| FIB, g/L (median [IQR]) | 2.63 [2.28, 3.12] | 2.58 [2.26, 3.01] | 2.81 [2.42, 3.37] | <.001* |
| ALB, g/L (median [IQR]) | 40.80 [38.00, 43.15] | 41.00 [38.70, 43.50] | 39.00 [36.00, 43.00] | <.001* |
| FAR (median [IQR]) | 6.46 [5.50, 7.81] | 6.25 [5.42, 7.40] | 7.36 [5.94, 8.61] | <.001* |
*p < .05.
Abbreviations: AF, atrial fibrillation; ALB, albumin; DNT, door‐to‐needle time; FAR, fibrinogen‐to‐albumin ratio; FBG, fasting blood glucose; FIB, fibrinogen; Hba1c, glycosylated hemoglobin; Hs‐CRP, high‐sensitivity C‐reactive protein; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; OTT, the time from onset to treatment; TIA, transient ischemic attack; TOAST, the Trial of Org 10172 in Acute Stroke Treatment.