TABLE 4.
Baseline characteristics and laboratory results of patients in the low (≤7.57) and high (>7.57) FAR groups.
| Variable | All patients (n = 591) | Low FAR (n = 419) | High FAR (n = 172) | p Value |
|---|---|---|---|---|
| Characteristic | ||||
| Age (median [IQR]) | 68.00 [61.00, 79.00] | 66.00 [60.00, 76.00] | 73.00 [64.00, 84.00] | <.001* |
| Gender (male), N (%) | 351 (59.4) | 259 (61.8) | 92 (53.5) | .075 |
| Outcomes (poor outcome), N (%) | 147 (24.9) | 75 (17.9) | 72 (41.9) | <.001* |
| Stroke severity, N (%) | <.001* | |||
| NIHSS score (0–4) | 272 (46.0) | 214 (51.1) | 58 (33.7) | |
| NIHSS score (5–15) | 252 (42.6) | 170 (40.6) | 82 (47.7) | |
| NHISS score (16–20) | 42 (7.1) | 24 (5.7) | 18 (10.5) | |
| NIHSS score (21–42) | 25 (4.2) | 11 (2.6) | 14 (8.1) | |
| Subgroup of TOAST, N (%) | <.001* | |||
| Small‐artery occlusion | 238 (40.3) | 187 (44.6) | 51 (29.7) | |
| Large‐artery atherosclerosis | 166 (28.1) | 126 (30.1) | 40 (23.3) | |
| Cardio‐embolism | 140 (23.7) | 81 (19.3) | 59 (34.3) | |
| Undetermined etiology | 36 (6.1) | 20 (4.8) | 16 (9.3) | |
| Other etiology | 11 (1.9) | 5 (1.2) | 6 (3.5) | |
| Infarct location, n (%) | 1.000 | |||
| Anterior circulation | 459 (77.7) | 325 (77.6) | 134 (77.9) | |
| Posterior circulation | 132 (22.3) | 94 (22.4) | 38 (22.1) | |
| DNT (median [IQR]) | 47.0 [34.0, 70.0] | 46.0 [34.0, 69.0] | 49.0 [35.0, 72.3] | .369 |
| OTT (median [IQR]) | 132.0 [96.0, 175.0] | 132.5 [100.0, 180.5] | 130.0 [89.5, 165.3] | .107 |
| Hypertension, N (%) | 415 (70.2) | 288 (68.7) | 127 (73.8) | .257 |
| Diabetes, N (%) | 153 (25.9) | 105 (25.1) | 48 (27.9) | .539 |
| Smoking, N (%) | 247 (41.8) | 185 (44.2) | 62 (36.0) | .085 |
| Drinking, N (%) | 105 (17.8) | 80 (19.1) | 25 (14.5) | .231 |
| AF, N (%) | 127 (21.5) | 75 (17.9) | 52 (30.2) | .001* |
| Prior stroke or TIA, N (%) | 90 (15.2) | 61 (14.6) | 29 (16.9) | .561 |
| Laboratory results | ||||
| Hs‐CRP, mg/L (median [IQR]) | 3.00 [1.60, 5.37] | 2.78 [1.60, 5.00] | 3.48 [1.69, 10.00] | <.001* |
| FBG, mmol/L (median [IQR]) | 6.90 [6.00, 8.80] | 6.80 [5.90, 8.45] | 7.35 [6.20, 9.10] | .024* |
| Hba1c (%) (median [IQR]) | 5.90 [5.60, 6.60] | 5.90 [5.50, 6.60] | 6.00 [5.70, 6.70] | .034* |
| FIB, g/L (median [IQR]) | 2.63 [2.28, 3.12] | 2.45 [2.15, 2.68] | 3.37 [3.13, 3.69] | <.001* |
| ALB, g/L (median [IQR]) | 40.80 [38.00, 43.15] | 42.00 [39.00, 44.00] | 38.40 [35.48, 40.70] | <.001* |
*p < .05.
Abbreviations: AF, atrial fibrillation; ALB, albumin; DNT, door‐to‐needle time; FAR, fibrinogen‐to‐albumin ratio; FBG, fasting blood glucose; FIB, fibrinogen; Hba1c, glycosylated hemoglobin; Hs‐CRP, high‐sensitivity C‐reactive protein; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; OTT, the time from onset to treatment; TIA, transient ischemic attack; TOAST, the Trial of Org 10172 in Acute Stroke Treatment.