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. 2023 Dec 18;17:1288676. doi: 10.3389/fncel.2023.1288676

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Copyright © 2023 Falco, Fabbiani, Maciel, Valdivia, Vitureira and Russo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local blockade of P2X7r reduces injury-induced proliferation. (A) Experimental design. (B) Numerous nuclei are labeled for EdU in the ependyma of control animals after 8 DPI. (C) The number of EdU + nuclei is lower when the hydrogel injected in the lesion was loaded with the selective P2X7r antagonist AZ10606120 (10 μM). (D) Boxplot showing the number of EdU + nuclei in control animals was significantly higher than that of mice in which the P2X7r was blocked by AZ10606120 (Mann-Whitney test, p < 0.0001) The line of the boxplots represents the median of the values for each sample. ****p < 0.0001. Scale bars: (B,C), 10 μm.