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. 2023 Dec 18;5:1244596. doi: 10.3389/ftox.2023.1244596

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Copyright © 2023 Alakhtar, Guilbert, Subramaniam, Caruana, Makhani, Baglole and Mann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AAV-PCSK9^DY increases circulating soluble endothelial cell activation markers, which is not altered by JUUL aerosol exposure. Adhesion molecules (A) sICAM-1, (B) sPECAM-1, (C) sE-selectin, and (D) sP-selectin were assessed in the serum of control (open squares) and hyperlipidemic mice via multi-plex ELISA. AAV-PCSK9^DY mice were exposed to air (black circles), PG/VG (black squares), or Mango-flavored JUUL (black triangles). Soluble adhesion molecule levels for uninfected, unexposed C57BL/6J mice are shown for comparison. Results are expressed as the mean ± SD. n = 3–4.