Table 3.
Univariate and multivariate analyses of the association of treatment delay intervals with cancer-specific survival (CSS)
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Months from diagnosis to treatment | ||||
| Immediate | 1.00(ref) | ref | 1.00(ref) | ref |
| Intermediate-delay | 2.03(1.95,2.12) | <0.001 | 1.06(1.01,1.11) | 0.010 |
| Long-delay | 2.07(1.79,2.40) | <0.001 | 1.01(0.87,1.17) | 0.888 |
| Age | 1.03(1.03,1.04) | <0.001 | 1.02(1.01,1.02) | <0.001 |
| Race | ||||
| Black | 1.00(ref) | ref | 1.00(ref) | ref |
| White | 0.83(0.77,0.90) | <0.001 | 0.84(0.78,0.91) | <0.001 |
| Other | 0.66(0.61,0.72) | <0.001 | 0.82(0.76,0.90) | <0.001 |
| Rural-Urban | ||||
| Metropolitan | 1.00(ref) | ref | 1.00(ref) | ref |
| Nonmetropolitan | 1.12(1.05,1.20) | 0.001 | 1.02(0.94,1.10) | 0.679 |
| Unknown | 1.31(0.71,2.44) | 0.389 | 1.09(0.59,2.04) | 0.779 |
| Marriage | ||||
| Married | 1.00(ref) | ref | 1.00(ref) | ref |
| Single | 1.16(1.11,1.21) | <0.001 | 1.13(1.08,1.18) | <0.001 |
| Unknown | 1.02(0.92,1.14) | 0.702 | 0.96(0.86,1.07) | 0.485 |
| Median household income inflation | ||||
| < $35,000 | 1.00(ref) | ref | 1.00(ref) | ref |
| $35,000 - $55,000 | 0.90(0.76,1.06) | 0.212 | 0.95(0.79,1.13) | 0.541 |
| $55,000 - $75,000 | 0.80(0.68,0.95) | 0.010 | 0.88(0.73,1.05) | 0.160 |
| >$75,000 | 0.74(0.62,0.87) | <0.001 | 0.83(0.69,0.99) | 0.042 |
| Stage | ||||
| I | 1.00(ref) | ref | 1.00(ref) | ref |
| II | 3.52(3.11,3.98) | <0.001 | 3.39(2.99,3.85) | <0.001 |
| III | 10.12(9.22,11.10) | <0.001 | 8.01(7.21,8.89) | <0.001 |
| IV | 16.14(14.68,17.75) | <0.001 | 10.86(9.74,12.11) | <0.001 |
| Histology | ||||
| Serous | 1.00(ref) | ref | 1.00(ref) | ref |
| Mucinous | 0.26(0.22,0.29) | <0.001 | 1.33(1.15,1.54) | <0.001 |
| Endometrioid | 0.20(0.18,0.22) | <0.001 | 0.69(0.61,0.78) | <0.001 |
| Clear | 0.49(0.44,0.53) | <0.001 | 1.49(1.34,1.64) | <0.001 |
| Other epithelial | 1.37(1.27,1.48) | <0.001 | 1.43(1.33,1.55) | <0.001 |
| Non-epithelial | 0.27(0.24,0.31) | <0.001 | 0.86(0.75,0.98) | 0.022 |
| Grade | ||||
| Well differentiated | 1.00(ref) | ref | 1.00(ref) | ref |
| Moderately differentiated | 2.95(2.48,3.51) | <0.001 | 1.99(1.67,2.38) | <0.001 |
| Poorly differentiated/undifferentiated | 7.64(6.53,8.95) | <0.001 | 2.44(2.07,2.88) | <0.001 |
| Unknown | 6.86(5.85,8.06) | <0.001 | 2.29(1.94,2.71) | <0.001 |
| Therapy | ||||
| NACT | 1.00(ref) | ref | 1.00(ref) | ref |
| Primary surgical therapy | 0.49(0.46,0.51) | <0.001 | 0.89(0.84,0.94) | <0.001 |
| No chemotherapy and/or surgery | 0.46(0.43,0.49) | <0.001 | 1.39(1.30,1.49) | <0.001 |
| Residual | ||||
| No residual lesion | 1.00(ref) | ref | 1.00(ref) | ref |
| ≤1cm | 3.37(3.14,3.61) | <0.001 | 1.65(1.54,1.77) | <0.001 |
| >1cm | 3.87(3.63,4.13) | <0.001 | 1.83(1.71,1.96) | <0.001 |
| Unknown | 2.20(2.09,2.31) | <0.001 | 1.50(1.42,1.58) | <0.001 |
Abbreviation NACT: Neoadjuvant chemotherapy