Figure 3.

Intramyocardial injection of human extracellular vesicles (EVs) reduce inflammatory infiltrates and oxidative stress in a model of rat sterile pericarditis. (A) Representative images from sham, talc + vehicle and talc + EV treated animals showing inflammatory infiltrates using hematoxylin and eosin staining. Scale bar 2 or 0.2 mm, indicated. (B) Random field analysis showing that increasing EV dose had an immediate and progressive inhibitory effect on inflammatory infiltrates (hematoxylin and eosin staining) within talc treated animals (n=5). Dotted line indicates baseline (sham). (C) Effect of pericarditis and EV treatment on myeloperoxidase activity (n=5). One-way ANOVA with individual-mean comparisons by Šídák's multiple comparisons test. *P<0.05 vs. talc + vehicle treated animals. #P<0.05 vs. sham. EV, extracellular vesicles.