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OrgOCs platform for assessing drug metabolism and safety in precision medicine. (A) Recapitulation of first-pass metabolism of anti-cancer drug with intestinal organoids-on-chips. Adapted with permission 281. Copyright 2021 Multidisciplinary Digital Publishing Institute (MDPI). (B) Liver-heart organoids-on-chips allowed to explore the hepatic metabolism-dependent cardiotoxicity of clomipramine. Adapted with permission 284. Copyright 2021 AIP Publishing.
