Table 1.
Commercial COVID-19 mRNA-LNP vaccines (Partial).
| Category | Moderna | BioNTech/Pfizer |
|---|---|---|
| Product | mRNA-1273 | BNT162b2 |
| mRNA dose | 100 μg | 30 μg |
| Ionizable cationic lipid | SM-102 | ALC-0315 |
| Phospholipid | DSPC | DSPC |
| Cholesterol | Cholesterol | Cholesterol |
| PEG-lipid | DMG-PEG2000 | ALC-0159 |
| Molar ratios | 50:10:38.5:1.5 | 46.3:9.4:42.7:1.6 |
| Molar N/P ratios | 6 | 6 |
| Other excipients | Potassium chloride | Sodium acetate |
| Sodium chloride | Sucrose | |
| Sucrose | Water for injection | |
| Water for injection | / |
Note: SM-102, heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate; ALC-0315, (4-hydroxybutyl)azanediyl bis(hexane-6,1-diyl)bis(2-hexyldecanoate); ALC-0159, (2-hexyldecanoate), 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; DMG-PEG 2000, 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000.