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. 2024 Jan 1;14(2):480–495. doi: 10.7150/thno.89592

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Inhibited Purkinje cells in the 5th lobule of the cerebellar vermis (5Cb) prolonged the recovery of consciousness after 3% sevoflurane exposure in mice. (A) Viral-genetic manipulation for expressing eNpHR-mCherry (red) in the 5Cb. (B) Top panel: Optical induced inhibition during burst suppression; Bottom panel: Optical induced inhibition during loss of consciousness (LOC) and recovery of consciousness (ROC). (C) Representative EEG recordings and spectrum during and after opto-inhibition in the mCherry control and Purkinje cells inhibited with eNpHR-mCherry. (D) The burst suppression ratio (BSR) per 1 min from burst suppression to wake state. (E, F) The time required to become LOC upon inhibition of Purkinje cells immediately after sevoflurane started (H) and the time needed to become ROC (I) upon inhibition of Purkinje cells immediately after sevoflurane termination. Data are mean ± SEM (n=5).