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. 2024 Jan 1;14(2):622–639. doi: 10.7150/thno.88759

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MYCi975 plus cisplatin induces the expression of CD8⁺ T cell‑attracting chemokines in HNSCC cells. (A) The mRNA expression levels of IFNB, CXCL9, CXCL10, and CXCL11 in HN6 cells induced under different conditions as indicated. Means ± SD are shown. *P < 0.05 and **P < 0.01 using one-way ANOVA. (B) The mRNA expression levels of IFNB, CXCL9, CXCL10, and CXCL11 in SCC15 cells induced under different conditions as indicated. Means ± SD are shown. *P < 0.05 and **P < 0.01 using one-way ANOVA. (C) A diagram of the mechanism by which MYCi975 plus cisplatin eliminate CSCs and activate antitumor immunity to overcome cisplatin resistance.