Table 6.
Relevant Parameters of the RT/IMRT in the AM-BM (RT, IMRT, etc.)
| Cancer | Species | Injection method | Injection site | Cell line | Cells number/volume (cells/µl) |
Irradiator | Irradiation time (days) | Dose/fraction (Gy/F) |
Dose rate (Gy/min) | Irradiation method | Combination Therapy | Effect | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Melanoma | 10w nude rats | ICB | Right caudate nucleus | MRA 27 | 1×106/NA | linear accelerator (Siemens Medical Systems, Concord, CA). | 12-14 | 15/3 | NA | RT | Boron neutron capture therapy BNCT (BNCT i.v.) BPA (500 mg/kg) containing an equivalent amount of 10B (27 mg B/kg). |
Survival: RT ↑; Neutron + RT ↑↑; BPA + BNCT+ RT ↑↑↑; BPA + BNCT +RT ↑↑↑ |
48 |
| Melanoma | 6w Female nude mice | ICB | 1 mm anterior to bregma, -1 mm lateral, and -3 mm in deep of the cortex surface | B16-F10 | 1×104/NA | Faxitron CP-160 irradiator | NA | 14/7 | 1.0 Gy/min | IMRT | 5-aminolevulinic acid(5-ALA) 200 mg/kg 4 h before X-ray irradiation |
In vivo Tumor size RT ↓ 5-ALA+RT ↓↓ In vitro γH2AX RT ↑ 5-ALA+RT ↑↑ |
101 |
| Breast Cancer | 6w Female BALB/c nude mice | ICB | The brain 2 mm posterior, 1.5 mm right lateral, and 3.5 mm deep from the bregma | MDA-MB-231(Br) | 2×105/2 PBS |
X‐Rad 320 (Precision X‐Ray, North Branford, CT) | 14 | 15/5 | NA | RT | Metformin (300 mg/kg/d) 1 week after Tumor implantation |
Metformin increases the concentration of lactate in MDA-MB‐231-Br cells by suppressing MCT4 protein, thereby enhancing the antitumor effect of RT | 65 |
| Breast Cancer | Female Berlin-Druckery IX (BD-IX) rats | ICB | Left striatum | ENU1564 | 1×103/NA | SARRP irradiator (Xstrahl, Camberley, UK) | 20 | 25 /1 | NA 225 kV x-rays |
IMRT | NA | Tumor volumes RT ↓ |
112 |
| Breast Cancer | Female immunodeficient nude mice | ICB | Right hemisphere | MDA-MB-231-BR | 1×105/5 PBS |
small-animal radiation research platform (Xstrahl, Camberley, England) | NA | 10 /1 | 2.42 Gy/min 225 kV [peak] |
IMRT low-linear energy transfer radiation |
Microbubble | Tumor volumes: RT ↓RT+ O2 MBs ↓; RT+O2 MBs + US ↓↓ Median Survival: RT ↑; RT+ O2 MBs ↑; RT+O2 MBs + US ↑↑ |
86 |
| Breast Cancer | 4-6w Female nude mice |
ICB | Caudate nucleus | MDA-MB-231-BR | 1×106/5 | Pantak irradiator | 3 | 5 /1 | 2.28 Gy/min | RT | TT: vorinostat (75 mg/kg) |
In vivo Tumor volume RT ↓ RT +vorinostat↓↓ Survival RT ↑ RT +vorinostat↑↑ In vitro γH2AX RT ↑ RT +vorinostat↑↑ Mitotic catastrophe RT ↑ RT +vorinostat↑↑ |
47 |