Table 7.
A Comprehensive and Scientific Template for Reporting Experiments Involving Animal Models of Brain Metastasis Radiotherapy
| Parameter | Notes on Reporting |
|---|---|
| Study design | |
| Assessment time-points post-irradiation | in Weeks |
| Serial assessment of >=1 parameter completed? | Yes/No |
| Combination therapy | Immunotherapy, Chemotherapy, Targeted therapy |
| Sequence of combination therapy | — |
| Tumor parameters | |
| Tumor type | Lung cancer, Breast cancer, Melanoma |
| Injection method | Orthotopic injection, Intracardiac injection, Carotid artery injection, Tail vein injection |
| Time of cell injection | in Weeks |
| Number of tumor cells | — |
| Cell line | A549, LLC, 4T1, B16-F10 |
| Injection site | Frontal lobe, Striatum |
| Tumor size | |
| Radionuclide imaging | Yes/No |
| Magnetic resonance imaging (MRI) | Yes/No |
| Bioluminescence imaging (BLI) | Yes/No |
| CT/PET-CT | Yes/No |
| Animal character | |
| Animal species | Mouse or Rat |
| Animal strain | C57BL/6, BLAB/c, SCID, SD |
| Sex | Male or Female |
| Gene modifications/spontaneous mutations | — |
| Irradiation | |
| Irradiation time (after/before irradiation) | in Weeks |
| Target volume | Whole Body, Head, Whole Brain, or Partial Brain |
| Form of ionizing radiation | X-rays, Gamma rays, Electrons, Heavy ions |
| Energy of radiation | in kV or MV |
| Dose rate | in Gy/min |
| Field arrangement | — |
| Radiation device used | Brand & Model |
| Dose fractionation | |
| Total physical irradiation dose | in Gray |
| Total fractions | — |
| Duration over which irradiation was given | in Days |
| Functional analyses | |
| Blood-brain barrier permeability | Yes/No |
| Animal weight | Yes/No |
| Tumor size | Yes/No |
| Radiotherapy-related markers | Yes/No |
| Invasive hemodynamics | Yes/No |
| Tumor markers | Yes/No |
| Radiography | Yes/No |