Table 1.
Bidirectional MR Results of Type 2 diabetes and gut microbiota
| Level | Exposure | Outcome | Method | NSNP | Beta(95%CI) | P | Directional pleiotropy | Cochrane's Q-statistic (P) | Steiger P | |
|---|---|---|---|---|---|---|---|---|---|---|
| Egger intercept (P) | MRPRESSO RSSobs (P) | |||||||||
| T2D on Gut microbiota | ||||||||||
| Genus | T2D | Butyrivibrio | MR Egger | 124 | -0.108(-0.278,0.061) | 0.212 | 0.001 (0.870) |
151.361 (0.115) |
143.251 (0.102) |
6.51E-211 |
| Weighted median | 124 | -0.067(-0.195,0.061) | 0.305 | |||||||
| IVW | 124 | -0.096(-0.169,-0.022) | 0.011 | |||||||
| Genus | T2D | Catenibacterium | MR Egger | 114 | 0.046(-0.127,0.22) | 0.603 | 0.004 (0.530) |
126.627 (0.378) |
121.413 (0.277) |
1.51E-202 |
| Weighted median | 114 | 0.044(-0.096,0.184) | 0.537 | |||||||
| IVW | 114 | 0.096(0.02,0.172) | 0.013 | |||||||
| Genus | T2D | Olsenella | MR Egger | 124 | 0.011(-0.14,0.162) | 0.886 | 0.005 (0.363) |
135.497 (0.416) |
122.308 (0.501) |
5.77E-220 |
| Weighted median | 124 | 0.058(-0.072,0.188) | 0.379 | |||||||
| IVW | 124 | 0.074(0.008,0.14) | 0.027 | |||||||
| Family | T2D | Oxalobacteraceae | MR Egger | 125 | 0.124(-0.011,0.258) | 0.073 | -0.005 (0.307) |
154.722 (0.106) |
136.319 (0.212) |
1.47E-212 |
| Weighted median | 125 | 0.065(-0.037,0.167) | 0.215 | |||||||
| IVW | 125 | 0.061(0.002,0.119) | 0.043 | |||||||
| Genus | T2D | Erysipelotrichaceae UCG003 | MR Egger | 14 | 0.203(-0.418,0.823) | 0.534 | -0.004 (0.842) |
23.752 (0.097) |
20.351 (0.087) |
2.09E-15 |
| Weighted median | 14 | 0.173(0.011,0.334) | 0.036 | |||||||
| IVW | 14 | 0.14(0.004,0.276) | 0.043 | |||||||
| Gut microbiota on T2D | ||||||||||
| Genus | Lachnoclostridium | T2D | MR Egger | 8 | 0.524(0.044,1.005) | 0.076 | -0.019(0.230) | 6.420(0.706) | 4.971(0.664) | 1.16E-23 |
| Weighted median | 8 | 0.179(0.03,0.328) | 0.019 | |||||||
| IVW | 8 | 0.206(0.095,0.316) | 0.000 | |||||||
| Genus | Streptococcus | T2D | MR Egger | 11 | 0.118(-0.239,0.474) | 0.533 | 0.002(0.874) | 19.848(0.147) | 13.161(0.215) | 4.19E-37 |
| Weighted median | 11 | 0.116(-0.013,0.245) | 0.077 | |||||||
| IVW | 11 | 0.146(0.046,0.246) | 0.004 | |||||||
| Genus | Actinomyces | T2D | MR Egger | 5 | 0.289(-0.185,0.763) | 0.318 | -0.016(0.514) | 3.149(0.837) | 2.163(0.706) | 4.13E-18 |
| Weighted median | 5 | 0.113(-0.008,0.234) | 0.067 | |||||||
| IVW | 5 | 0.114(0.023,0.205) | 0.014 | |||||||
| Family | Streptococcaceae | T2D | MR Egger | 13 | 0.122(-0.218,0.462) | 0.497 | -0.002(0.867) | 18.677(0.269) | 13.621(0.326) | 1.25E-44 |
| Weighted median | 13 | 0.087(-0.029,0.203) | 0.143 | |||||||
| IVW | 13 | 0.093(0.006,0.18) | 0.035 | |||||||
| Genus | unknown genus id.2041 | T2D | MR Egger | 6 | 0.204(-0.072,0.48) | 0.222 | -0.010(0.472) | 10.065(0.311) | 6.910(0.227) | 8.97E-19 |
| Weighted median | 6 | 0.058(-0.056,0.172) | 0.319 | |||||||
| IVW | 6 | 0.099(0.006,0.192) | 0.037 | |||||||
MR, mendelian randomization; T2D, Type 2 diabetes; IVW, inverse variance weighted; NSNPs, number of single nucleotide polymorphisms; beta, mendelian randomization effect estimate