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. 2024 Jan 1;21(2):319–331. doi: 10.7150/ijms.89308

Figure 2.

Figure 2

The overexpressed lncRNA DLEU2 in lung cancer cell lines was downregulated after Huaier treatment. (A) Heatmap showing the significantly co-upregulated and co-downregulated lncRNAs of A549 and H1299 cells treated with 4 mg/mL Huaier for 48 h. The lncRNA expression profile was based on Huaier-treated versus untreated A549 and H1299 cells at fold change > 2 and false discovery rate (FDR) < 0.001. Red represented high expression and blue represented low expression. (B) Heatmap displaying the indicated differentially expressed lncRNAs. Six co-downregulated lncRNAs (CDK2AP1, LMNTD2-AS1, CMAS, SNHG5, FGD5-AS1, DLEU2) and two co-upregulated lncRNAs (DNLZ, SNAPIN). (C) The qRT-PCR to verify the co-upregulated and co-downregulated lncRNAs. (D and E) DLEU2 expression in lung adenocarcinoma and lung squamous carcinoma compared to the noncancerous lung tissues from UALCAN cancer database. (F) The qRT-PCR for DLEU2 expression in NSCLC cells and the noncancerous lung epithelial cell line BEAS-2B.