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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Hepatology. 2023 Apr 17;77(5):1580–1592. doi: 10.1002/hep.32744

FIGURE 4.

FIGURE 4

Deletion of IL-33 or ST2 attenuates PHx-induced increase of serotonin in the portal blood and liver. (A) Immunohistochemistry (IHC) staining for ST2 in liver sections at 0, 3, and 12 h after PHx. The arrow points to a ST2-positive cell in the inset representative images from n = 3–8 mice/group were shown. Scale bar: 200 μm. (B-E) WT, IL-33−/− and ST2−/− mice were subjected to PHx. Portal vein sera and livers were collected at 0 and 12 h after PHx. Portal blood levels of endotoxin (B), total bile acid (C), and serotonin (D) were measured (n = 3-10/group). (E) Serotonin levels in liver tissues were also measured (n = 4-5/group). Two-way ANOVA was performed in (B), (C), (D), and (E)