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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Curr Osteoporos Rep. 2023 Mar 7;21(2):241–252. doi: 10.1007/s11914-023-00778-7

Fig. 1.

Fig. 1

Schematic of SP7 functions in chondrocytes, osteoblasts, and osteocytes. SP7 regulates osteoblast differentiation and bone formation through osteoblast target genes by recognizing AT-rich region. In osteocytes, SP7 regulates osteocyte maturation and intracortical remodeling through osteocyte target genes by recognizing TGA(G/T) TCA motif. SP7 also regulates chondrocyte differentiation and endochondral ossification. CC, chondrocyte; OB, osteoblast; Ocy, osteocyte; OC, osteoclast. Part of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/)