Table 1.
Baseline Characteristics for Patients Stratified by Primary Events
| Variables | Overall (N=8602) | Non-MACE (N=8080) | MACE (N=522) | P value |
|---|---|---|---|---|
| Four subgroups | <0.001 | |||
| SII-H/T2DM | 1440 (16.7) | 1311 (16.2) | 129 (24.7) | |
| SII-H/Non-T2DM | 2516 (29.2) | 2350 (29.1) | 166 (31.8) | |
| SII-L/T2DM | 1687 (19.6) | 1595 (19.7) | 92 (17.6) | |
| SII-L/Non-T2DM | 2959 (34.4) | 2824 (35.0) | 135 (25.9) | |
| Baseline characteristics | ||||
| Age, years | 58.41±10.19 | 58.35±10.17 | 59.29±10.41 | 0.041 |
| Male | 6611 (76.9) | 6197 (76.7) | 414 (79.3) | 0.187 |
| BMI, kg/m2 | 25.90±3.19 | 25.90±3.19 | 26.00±3.14 | 0.463 |
| Hypertension | 5547 (64.5) | 5197 (64.3) | 350 (67.0) | 0.224 |
| Dyslipidemia | 5741 (66.7) | 5381 (66.6) | 360 (69.0) | 0.287 |
| T2DM | 3956 (46.0) | 3661 (45.3) | 295 (56.5) | <0.001 |
| Smoking history | 4899 (57.0) | 4596 (56.9) | 303 (58.0) | 0.635 |
| MI history | 1617 (18.8) | 1488 (18.4) | 129 (24.7) | <0.001 |
| PCI history | 1958 (22.8) | 1819 (22.5) | 139 (26.6) | 0.034 |
| CABG history | 337 (3.9) | 310 (3.8) | 27 (5.2) | 0.159 |
| Stroke history | 903 (10.5) | 836 (10.3) | 67 (12.8) | 0.085 |
| PAD history | 637 (7.4) | 596 (7.4) | 41 (7.9) | 0.750 |
| ACS | 5070 (58.9) | 4767 (59.0) | 303 (58.0) | 0.702 |
| Laboratory tests | ||||
| Platelet, *109/L | 207.26±55.08 | 207.10±54.84 | 209.67±58.70 | 0.301 |
| Neutrophil, *109/L | 4.25±1.53 | 4.23±1.51 | 4.55±1.76 | <0.001 |
| Lymphocyte, *109/L | 1.95±0.64 | 1.95±0.64 | 1.99±0.64 | 0.192 |
| SII | 423.81 [310.25, 591.46] | 422.45 [310.04, 588.03] | 450.41 [319.81, 628.96] | 0.033 |
| Ln SII | 6.07±0.51 | 6.07±0.51 | 6.13±0.56 | 0.014 |
| FBG, mmol/L | 6.26±2.22 | 6.23±2.18 | 6.68±2.71 | <0.001 |
| HbA1c, % | 6.60±1.21 | 6.59±1.21 | 6.79±1.24 | <0.001 |
| TG, mmol/L | 1.52 [1.14, 2.08] | 1.53 [1.14, 2.08] | 1.46 [1.14, 2.09] | 0.526 |
| TC, mmol/L | 4.20±1.07 | 4.20±1.07 | 4.19±1.07 | 0.852 |
| HDL-C, mmol/L | 1.04±0.28 | 1.04±0.28 | 1.03±0.26 | 0.792 |
| LDL-C, mmol/L | 2.50±0.90 | 2.50±0.90 | 2.49±0.90 | 0.728 |
| hsCRP, mg/L | 1.57 [0.79, 3.46] | 1.56 [0.78, 3.40] | 1.72 [0.91, 4.15] | 0.002 |
| Creatinine, μmol/L | 75.16±15.44 | 75.10±15.43 | 76.01±15.44 | 0.195 |
| eGFR, mL/min/1.73m2 | 102.91±22.04 | 102.97±21.93 | 102.08±23.65 | 0.373 |
| LVEF, % | 63.12±7.12 | 63.19±7.07 | 62.09±7.83 | 0.001 |
| Medications | ||||
| DAPT | 8407 (97.7) | 7894 (97.7) | 513 (98.3) | 0.479 |
| β-blocker | 7739 (90.0) | 7259 (89.8) | 480 (92.0) | 0.138 |
| CCB | 4241 (49.3) | 3967 (49.1) | 274 (52.5) | 0.145 |
| Statins | 8258 (96.0) | 7757 (96.0) | 501 (96.0) | 1.000 |
| Nitrate | 8417 (97.8) | 7907 (97.9) | 510 (97.7) | 0.932 |
| Angiography data | ||||
| LM/three-vessel disease | 3787 (44.0) | 3506 (43.4) | 281 (53.8) | <0.001 |
| CTO | 1430 (16.6) | 1305 (16.2) | 125 (23.9) | <0.001 |
| SYNTAX score | 10.00 [6.00, 16.00] | 10.00 [5.50, 16.00] | 11.00 [6.00, 17.50] | 0.005 |
| Number of stents | 2.00 [1.00, 2.00] | 2.00 [1.00, 2.00] | 2.00 [1.00, 3.00] | 0.001 |
| Total length of stents, mm | 36.00 [23.00, 55.00] | 36.00 [23.00, 55.00] | 40.00 [24.00, 57.75] | 0.001 |
| Average diameter of stents, mm | 3.00 [2.75, 3.50] | 3.00 [2.75, 3.50] | 3.00 [2.71, 3.33] | 0.004 |
Note: Values are expressed as mean ± SD or median (IQR) for continuous variables and percentage for categorical variables.
Abbreviations: SD, standard deviation; IQR, interquartile range; MACE, major adverse cardiovascular events; SII, systematic immune-inflammation index; T2DM, type 2 diabetes mellitus; BMI, body mass index; MI, myocardial infarction; PCI, percutaneous coronary intervention; CABG, coronary artery bypass grafting; PAD, peripheral artery disease; ACS, acute coronary syndrome; FBG, fasting blood glucose; HbA1c, glycosylated hemoglobin A1c; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; DAPT, dual antiplatelet therapy; CCB, calcium channel blocker; LM, left main; SYNTAX, synergy between PCI with taxus and cardiac surgery.