Table 1.
Demographic and clinical characteristics of study participants
Characteristics | APOE ε4 non-carrier (N=95) | APOE ε4 carrier (N=86) | p |
---|---|---|---|
Age (yr) | 75.9±6.8 | 75.6±6.3 | 0.739 |
Sex | 0.054 | ||
Male | 43 (45.3) | 26 (30.2) | |
Female | 52 (54.7) | 60 (69.8) | |
Education years (yr) | 9.8±5.6 | 11.6±4.6 | 0.021 |
Global FMM SUVRPONS | 0.73±0.10 | 0.77±0.09 | 0.026 |
Cognitive function | |||
MMSE-K | 23.1±4.3 | 24.1±2.9 | 0.067 |
CERAD-K TM | 22.6±7.0 | 22.2±6.8 | 0.659 |
CERAD-K VF | 10.6±3.8 | 11.9±3.5 | 0.016 |
CERAD-K BNT | 9.6±3.1 | 10.6±2.1 | 0.010 |
CERAD-K CP | 9.6±1.7 | 9.8±1.5 | 0.355 |
CERAD-K CR | 2.7±1.8 | 2.5±2.0 | 0.651 |
CERAD-K total | 52.5±12.1 | 54.6±9.8 | 0.194 |
TMT B (s) | 249.1±70.2 | 229.1±77.0 | 0.070 |
Stroop Word-Color | 26.0±10.1 | 27.6±10.6 | 0.294 |
BMI (kg/m2) | 23.9±3.8 | 23.7±3.1 | 0.656 |
<23 (normal) | 39 (41.1) | 35 (40.7) | 0.980 |
23–25 (overweight) | 23 (24.2) | 20 (23.3) | |
>25 (obese) | 33 (34.7) | 31 (36.0) | |
SMI (kg/m2) | 6.5±1.2 | 6.2±1.0 | 0.187 |
BFMI (kg/m2) | 7.7±3.1 | 7.9±2.6 | 0.668 |
Visceral fat area (cm2) | 96.9±41.2 | 101.2±37.4 | 0.470 |
Waist/hip circumference ratio | 0.88±0.06 | 0.88±0.06 | 0.807 |
Values are presented as mean±standard deviation or number (%).
APOE, apolipoprotein E; SUVRPONS, standardized uptake value ratios of [18F]flutemetamol (FMM), using pons as a reference region; MMSE-K, the Korean version of Mini Mental Status Examination; CERAD-K, Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet; TM, Total Memory; VF, Verbal Fluency; BNT, Boston Naming Test; CP, Constructional Praxis; CR, Constructional Recall; TMT, Trail Making Test; BMI, body mass index; SMI, skeletal muscle index; BFMI, Body fat mass index