TABLE 3.
Biopsy results and DCGF - Unadjusted Cox proportional hazards analysis.
| Variables a | Hazard ratio (95% confidence interval) | p-value | Data (n) |
|---|---|---|---|
| Biopsy variables | |||
| Morphologic single lesion scores | |||
| C4d (c4d) | 1.58 (0.91–2.74) | 0.102 | 75 |
| Glomerulitis (g) | 0.88 (0.62–1.24) | 0.46 | 72 |
| Peritubular capillaritis (ptc) | 1.17 (0.57–2.41) | 0.67 | 75 |
| Glomerular double contours (cg) | 2.72 (1.39–5.33) | 0.004 | 73 |
| Interstitial fibrosis (ci) | 1.75 (0.88–3.50) | 0.11 | 75 |
| Tubular atrophy (ct) | 1.82 (1.19–2.78) | 0.006 | 75 |
| Vascular fibrous intimal thickening (cv) | 1.00 (0.67–1.49) | >0.99 | 63 |
| Morphologic indices | |||
| AI (g+ptc+v+C4d) | 1.39 (0.67–2.87) | 0.38 | 61 |
| AI3comp (g+ptc+C4d) | 1.20 (0.76–1.89) | 0.43 | 73 |
| CI (ci+ct+cv+[cgx2]) | 2.83 (1.24–6.43) | 0.013 | 61 |
| CI3comp (ci+ct+[cgx2]) | 2.90 (1.51–5.57) | 0.001 | 73 |
| Molecular scores | |||
| ABMRProb | 0.94 (0.52–1.68) | 0.83 | 75 |
| IRRAT | 2.66 (1.56–4.55) | <0.001 | 75 |
| ciprob | 2.71 (1.32–5.54) | 0.006 | 75 |
| Clinical/immunological variables | |||
| Variables recorded at transplantation | |||
| Recipient age (years) | 0.50 (0.31–0.81) | 0.005 | 75 |
| Male sex | 0.87 (0.43–1.77) | 0.71 | 75 |
| Deceased donor | 0.55 (0.24–1.23) | 0.14 | 75 |
| Donor age (years) | 0.98 (0.50–1.95) | 0.96 | 75 |
| Prior kidney transplant | 1.15 (0.54–2.45) | 0.72 | 73 |
| HLA mismatch (A, B, DR) | 0.79 (0.42–1.49) | 0.47 | 73 |
| HLA mismatch (A, B, C, DRB1, DQB1) | 0.73 (0.44–1.21) | 0.22 | 58 |
| Variables recorded at index biopsy | |||
| Time to biopsy (years) | 1.54 (0.93–2.55) | 0.095 | 75 |
| eGFR (ml/min/1.73m2) | 0.23 (0.11–0.48) | <0.001 | 75 |
| UPCR at biopsy (mg/g) | 2.47 (1.33–4.60) | 0.004 | 75 |
| DSA MFI ≥10000 | 1.93 (0.93–3.98) | 0.076 | 73 |
| Tacrolimus-based immunosuppression | 1.21 (0.56–2.64) | 0.63 | 75 |
| Anti-rejection treatment | 0.83 (0.41–1.67) | 0.60 | 75 |
ABMR, antibody-mediated rejection; AI, activity index; cg, glomerular double contours; CI, chronicity index; ci, interstitial fibrosis; ciprob, molecular classifier reflecting the probability of histologic ci lesion score >1; ct, tubular atrophy; cv, intimal fibrous thickening; DCGF, death-censored graft survival; DSA, donor-specific antibody; eGFR, estimated glomerular filtration rate; g, glomerulitis; IRRAT, transcript set associated with injury-repair response; MFI, mean fluorescence intensity; ptc, peritubular capillaritis; UPCR, urinary protein/creatinine ratio; v, intimal arteritis.
For continuous and ordinal categorical variables, hazard ratios were calculated per increase from the first to the third quartile.