Table 1.

Causes of sleep hyperhidrosis and proposed treatments.

Main Disorders Associated with Sleep Hyperhidrosis
Infectious: tuberculosis, brucellosis, bacterial pneumonia, human immunodeficiency virus, mononucleosis, cysticercosis, endocarditis Tumor: Lymphoma, leukemia, mesothelioma, inflammatory prostatic cancer, pheochromocytoma, POEMS syndrome Endocrinological/Metabolic: diabetes mellitus, hyperthyroidism, obesity, menopause, pheochromocytoma Autoimmune: giant cell arteritis, Takayasu arteritis, rheumatoid arthritis, sarcoidosis	Neurological Disorders: cervical spinal cord lesion, hypothalamic lesion, brainstem stroke, synucleinopathy, peripheral neuropathy Mental Disorders: panic disorder, anxiety disorder Sleep Disorders: sleep apnea, insomnia, restless legs syndrome, narcolepsy type 1 Miscellaneous: gastrointestinal reflux, Prinzmetal angina, environmental heat
Drug Effects on Sleep Hyperhidrosis
Reduction of night sweats	Increase of night sweats
Benzodiazepines: diazepam Anticholinergic: oxybutynin, glycopyrrolate Alpha-adrenergic agonists: clonidine Calcium channels inhibitors: diltiazem Carbonic anhydrase inhibitor: acetazolamide Immunomodulator: thalidomide Opioids: nabilone Hormonal replacement therapy	Cholinesterase inhibitors Cholinergic agents Selective serotonin and noradrenalin reuptake inhibitors antidepressants: venlafaxine, serotonin Antiviral: efavirenz Hypoglycemic agents Sodium oxybate Opioids

POEMS = polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes.