Table 3.
Risk factors for developing abdominal aortic calcification at diagnosis of essential thrombocythemia (N=94).
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Age >60 yr | 28.23 | 12.31–64.88 | <0.001 | 34.37 | 12.32–95.91 | <0.001 | |
| Male | 2.00 | 0.85–4.72 | 0.111 | - | - | - | |
| Volumetric splenomegaly | 1.07 | 0.59–2.03 | 0.833 | - | - | - | |
| WBC >11.0×109/L | 2.66 | 1.12–6.96 | 0.028 | 3.92 | 0.93–16.50 | 0.062 | |
| Monocyte >1.0×109/L | 6.94 | 1.59–20.33 | 0.010 | 4.38 | 0.25–77.29 | 0.313 | |
| Neutrophil/lymphocyte >4.0 | 2.28 | 0.88–5.90 | 0.089 | - | - | - | |
| Platelet >1,000×109/L | 1.29 | 0.61–2.72 | 0.509 | - | - | - | |
| LDH >1.5×ULN | 3.32 | 0.88–12.51 | 0.076 | - | - | - | |
| Positive JAK2V617F | 3.41 | 1.17–8.11 | 0.023 | 3.16 | 0.66–15.23 | 0.151 | |
| Positive CALR mutation | 0.44 | 0.11–1.75 | 0.242 | - | - | - | |
| Hypertension | 5.06 | 1.73–14.85 | 0.003 | 1.05 | 0.17–6.61 | 0.955 | |
| Diabetes mellitus | 3.97 | 1.07–14.79 | 0.040 | 4.74 | 0.41–54.23 | 0.211 | |
| Chronic kidney disease | 6.94 | 0.85–56.76 | 0.071 | - | - | - | |
| Dyslipidemia | 3.97 | 1.09–14.79 | 0.040 | 5.05 | 0.85–30.21 | 0.076 | |
| Smoking | 1.65 | 0.57–4.74 | 0.354 | - | - | - | |
Abbreviations: CALR, calreticulin; CI, confidence interval; LDH, lactate dehydrogenase; OR, odds ratio; ULN, upper limit of normal.