Table 5.
Risk factors for thrombotic vascular events occurring before or at diagnosis of essential thrombocythemia (N=94).
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Age >60 yr | 3.59 | 1.20–10.79 | 0.023 | 1.52 | 0.35–6.72 | 0.578 | |
| Male | 1.42 | 0.54–3.70 | 0.475 | - | - | - | |
| Volumetric splenomegaly | 0.37 | 0.14–1.03 | 0.056 | - | - | - | |
| WBC >11.0×109/L | 0.67 | 0.64–4.36 | 0.298 | - | - | - | |
| Monocyte >1.0×109/L | 2.06 | 0.54–7.84 | 0.287 | - | - | - | |
| Neutrophil/lymphocyte >4.0 | 3.22 | 1.20–8.68 | 0.021 | 1.84 | 0.57–5.69 | 0.322 | |
| Platelet >1,000×109/L | 2.33 | 0.86–6.25 | 0.095 | - | - | - | |
| LDH >1.5×ULN | 1.01 | 0.29–3.48 | 0.989 | - | - | - | |
| Positive JAK2V617F | 2.87 | 1.05–8.63 | 0.048 | 2.33 | 0.75–7.18 | 0.142 | |
| Hypertension | 1.57 | 0.59–4.22 | 0.368 | - | - | - | |
| Diabetes mellitus | 2.35 | 0.68–8.12 | 0.176 | - | - | - | |
| Chronic kidney disease | 5.03 | 1.36–18.55 | 0.015 | 3.66 | 0.95–14.06 | 0.059 | |
| Dyslipidemia | 0.84 | 0.25–2.87 | 0.787 | - | - | - | |
| Smoking | 1.93 | 0.66–5.64 | 0.227 | - | - | - | |
| AAC | 5.07 | 1.38–18.65 | 0.015 | 4.12 | 1.11–15.85 | 0.034 | |
Abbreviations: AAC, abdominal aortic calcification; CI, confidence interval; LDH, lactate dehydrogenase; OR, odds ratio; ULN, upper limit of normal.