Table 1.
Description of cholangiocarcinoma patients diagnosed between 2014 and 2017 in England, and subgroup who did not receive surgery up to 12 mo after diagnosis
|
Characteristics
|
Total
|
Did not receive surgery
|
| Total patients (n, %) | 8853 (100.0) | 7751 (100.0) |
| Age at diagnosis (yr) | ||
| 0-44 | 180 (2.0) | 117 (1.5) |
| 45-54 | 442 (5.0) | 320 (4.1) |
| 55-64 | 1231 (13.9) | 962 (12.4) |
| 65-74 | 2407 (27.2) | 1963 (25.3) |
| 75-84 | 2814 (31.8) | 2615 (33.7) |
| > 84 | 1779 (20.1) | 1774 (22.9) |
| Gender | ||
| Male | 4343 (49.1) | 3721 (48.0) |
| Female | 4510 (50.9) | 4030 (52.0) |
| Year of diagnosis | ||
| 2014 | 2055 (23.2) | 1802 (23.2) |
| 2015 | 2213 (25.0) | 1951 (25.2) |
| 2016 | 2259 (25.5) | 1983 (25.6) |
| 2017 | 2326 (26.3) | 2015 (26.0) |
| Route to diagnosis | ||
| Emergency presentation | 4276 (48.3) | 3975 (51.3) |
| TWW referral | 1490 (16.8) | 1306 (16.8) |
| Other GP referral | 1844 (20.8) | 1500 (19.4) |
| Other | 979 (11.1) | 729 (9.4) |
| Unknown | 264 (3.0) | 241 (3.1) |
| Stage at diagnosis | ||
| 1 | 310 (3.5) | 203 (2.6) |
| 2 | 686 (7.7) | 283 (3.7) |
| 3 | 330 (3.7) | 26 (2.9) |
| 4 | 3506 (39.6) | 3213 (41.5) |
| Missing | 4021 (45.4) | 3826 (49.4) |
| Tumour sub-type | ||
| CCA Other | 391 (4.4) | 378 (4.9) |
| eCCA | 1595 (18.0) | 1200 (15.5) |
| iCCA | 6867 (77.6) | 6173 (79.6) |
| Tumour morphology | ||
| Adenomas and adenocarcinomas | 8570 (96.8) | 7484 (96.6) |
| Other | 283 (3.2) | 267 (3.4) |
| English Index of Multiple Deprivation, income component | ||
| Quintile 1 (least deprived) | 1715 (19.4) | 1466 (18.9) |
| Quintile 2 | 1863 (21.0) | 1609 (20.8) |
| Quintile 3 | 1797 (20.3) | 1589 (20.5) |
| Quintile 4 | 1806 (20.4) | 1590 (20.5) |
| Quintile 5 (most deprived) | 1672 (18.9) | 1497 (19.3) |
| Charlson comorbidity index | ||
| 0 | 6220 (70.3) | 5340 (68.9) |
| 1 | 1140 (12.9) | 1025 (13.2) |
| 2 | 678 (7.7) | 623 (8.0) |
| 3+ | 815 (9.2) | 763 (9.8) |
| Underlying liver disease | ||
| No | 8044 (90.9) | 7101 (91.6) |
| Yes | 809 (9.1) | 650 (8.4) |
| Cancer Alliance at diagnosis | ||
| Cheshire and Merseyside | 427 (4.8) | 358 (4.6) |
| East Midlands | 795 (9.0) | 703 (9.1) |
| East of England-North | 524 (5.9) | 478 (6.2) |
| East of England-South | 558 (6.3) | 476 (6.1) |
| Greater Manchester | 521 (5.9) | 453 (5.8) |
| Humber, Coast and Vale | 310 (3.5) | 269 (3.5) |
| Kent and Medway | 251 (2.8) | 226 (2.9) |
| Lancashire and South Cumbria | 330 (3.7) | 285 (3.7) |
| North Central London | 141 (1.6) | 119 (1.5) |
| North East London | 173 (2.0) | 150 (1.9) |
| North West and South West London | 358 (4.0) | 302 (3.9) |
| Northern | 715 (8.1) | 628 (8.1) |
| Peninsula | 362 (4.1) | 311 (4.0) |
| Somerset, Wiltshire, Avon and Gloucestershire | 417 (4.7) | 374 (4.8) |
| South East London | 163 (1.8) | 141 (1.8) |
| South Yorkshire and Bassetlaw | 229 (2.6) | 201 (2.6) |
| Surrey and Sussex | 488 (5.5) | 442 (5.7) |
| Thames Valley | 234 (2.6) | 202 (2.6) |
| Wessex | 475 (5.4) | 419 (5.4) |
| West Midlands | 1013 (11.4) | 883 (11.4) |
| West Yorkshire and Harrogate | 369 (4.2) | 331 (4.3) |
| Treatment received | ||
| Surgery only | 507 (5.7) | 0 (0.0) |
| Surgery + systemic therapy | 367 (4.1) | 0 (0.0) |
| Surgery + stent insertion | 118 (1.3) | 0 (0.0) |
| Surgery + systemic therapy + stent insertion | 110 (1.2) | 0 (0.0) |
| Systemic therapy only | 1127 (12.7) | 1127 (14.5) |
| Stent insertion only | 1741 (19.7) | 1741 (22.5) |
| Systemic therapy + stent insertion | 415 (4.7) | 415 (5.4) |
| None of surgery, systemic therapy or stent insertion | 4468 (50.5) | 4468 (57.6) |
iCCA: Intrahepatic cholangiocarcinoma; eCCA: Extrahepatic cholangiocarcinoma; GP: General practitioner; TWW: Two week wait.