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. 2023 Nov 29;51(1):14. doi: 10.3892/or.2023.8673

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Copyright: © Ye et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — High SYNPO2 expression increases resistance to anti-PDL1 immune therapy. (A) Correlation of immune checkpoint genes with SYNPO2. (B) TIDE score. True presents numbers of positive immune responses; False presents numbers of negative immune responses; Red, resistance to immune checkpoint blocking; blue, positive response, P=P=1.3×10^{^−10}. (C) Differences in SYNPO2 expression in three immune infiltration types, The Deserted VS The Excluded P=0.0023. Correlation between SYNPO2 and (D) resting, P=6.3×10^{^−03} and (E) activated mast cell, P=7.0×10^{^−05}, (F) resting CD4 memory T and (G) monocyte infiltration in the IMVigor 210 cohort (n=348). SYNPO2, Synaptopodin-2; TPM, Transcript per million; PDL1, Programmed cell death 1 ligand 1; TIDE, Tumor Immune Dysfunction and Exclusion; ns, no significance. *, *** and **** indicate P<0.05, P<0.001, P<0.0001, respectively.