Table I.

Univariate and multivariate Cox proportional hazards analysis between SYNPO2 expression and overall survival for patients with Bladder Urothelial Carcinoma (BLCA).

		Univariate analysis		Multivariate analysis
Characteristic	n	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
T stage [T1&2 (n=124) vs. T3&4 (n=255)]	379	2.199 (1.515–3.193)	<0.001a	0.914 (0.203–4.123)	0.907
N stage [N0&1 (n=285) vs. N2&3 (n=84)]	369	2.273 (1.640–3.150)	<0.001a	2.050 (0.908–4.632)	0.084
M stage [M0 (n=202) vs. M1 (n=11)]	213	3.136 (1.503–6.544)	0.002a	0.696 (0.180–2.695)	0.600
Pathological stage [I&II (n=134) vs. III&IV (n=277)]	411	2.310 (1.596–3.342)	<0.001a	1.872 (0.334–10.492)	0.476
Radiation therapy [no (n=366) vs. yes (n=21)]	387	0.965 (0.475–1.964)	0.923
Sex [female (n=109) vs. male (n=304)]	413	0.849 (0.616–1.169)	0.316
Ethnicity [Asian&Black or African American (n=67) vs.	396	1.145 (0.731–1.794)	0.554
White (n=329)]
Weight [≤80 (n=204) vs. >80 kg (n=166)]	370	0.968 (0.709–1.323)	0.840
Height [≤170 cm (n=158) vs. >170 cm (n=206)]	364	1.100 (0.798–1.518)	0.561
BMI [≤25 (n=152) vs. >25 (n=211)]	363	0.978 (0.706–1.353)	0.892
Histological grade [high (n=389) vs. low (n=21)]	410	0.337 (0.083–1.360)	0.126
Smoking status [no (n=109) vs. yes (n=291)]	400	1.305 (0.922–1.847)	0.133
Primary therapy outcome	357	0.226 (0.162–0.315)	<0.001a	0.455 (0.218–0.949)	0.036a
[PD&SD (n=101) vs. PR&CR (n=256)]	413	1.421 (1.063–1.901)	0.018a	1.428 (0.727–2.803)	0.301
Age [≤70 (n=233) vs. >70 years (n=180)]	408	0.690 (0.488–0.976)	0.036a	1.635 (0.737–3.628)	0.226
Subtype [non-papillary (n=275) vs. papillary (n=133)]
Lymphovascular invasion	282	2.294 (1.580–3.328)	<0.001a	1.677 (0.732–3.843)	0.222
[no (n=130) vs. yes (n=152)]	413	1.609 (1.195–2.168)	0.002a	2.238 (1.093–4.582)	0.028a
SYNPO2 expression [low (n=207) vs. high (n=206)]

^aP<0.05. BMI, body mass index; PD, progressive disease; SD, Stable disease; PR, Partial response; CR, Complete response; SYNPO2, Synaptopodin-2. Bold text represents P<0.05.