Table 5.
Binary Logistic Regression Predicting the Likelihood of Having an Abnormal Neurologic Examination Among Patients With SCD Who Did Not Experience a Previous Major Neurologic Event
| Variable | Odds ratio | 95% CI | p Value |
| Sex (male) | 1.42 | 1.01–2.02 | 0.050 |
| Age at entry visit (y) | 1.01 | 0.99–1.03 | 0.179 |
| Smoking | 1.59 | 1.08–2.33 | 0.018 |
| BMI ≥25 kg/m2 | 1.36 | 0.80–2.32 | 0.254 |
| SBP | 0.99 | 0.97–1.02 | 0.881 |
| DBP | 0.99 | 0.96–1.02 | 0.647 |
| Previous history of | |||
| Eye disease | 2.76 | 1.63–4.68 | <0.001 |
| Aseptic necrosis | 1.57 | 1.06–2.33 | 0.024 |
| Osteomyelitis | 2.55 | 1.34–4.84 | 0.004 |
| Hand-foot syndrome | 1.48 | 1.04–2.12 | 0.029 |
| Renal insufficiency | 1.54 | 0.66–3.59 | 0.310 |
| Blood transfusion | 1.17 | 0.79–1.74 | 0.427 |
| Lung infarction | 1.49 | 0.70–3.16 | 0.293 |
| Painful crisis | 1.05 | 0.75–1.49 | 0.743 |
| Blood and liver tests | |||
| Reticulocytes (%) | 1.01 | 0.97–1.03 | 0.753 |
| Hemoglobin F (%) | 0.97 | 0.94–1.01 | 0.276 |
| Albumin <3.5 (g/dL) | 1.05 | 0.66–1.68 | 0.818 |
Abbreviations: BMI = body mass index; CI = confidence interval; DBP = diastolic blood pressure; LDH = lactate dehydrogenase; SBP = systolic blood pressure.