Asymmetric Michael addition of dimethyl malonate to a series of azachalcone derivatives in the presence of copper–amyloid complexes of P01^a.

Entry	R	2	Yield (%)	ee (%)
1	Ph	2a	78	38
2	4-CH3-C6H5	2b	75	31
3	4-NO2-C6H5	2c	29	29
4	4-Br-C6H5	2d	26	31
5	2-Naphthyl	2e	41	37

^aReaction conditions: 475 μM amyloid-like fibrils and 95 μM CuSO₄ in 20 mM MOPS buffer (pH 6.5) for 1 day at 0 °C. The yields and ee values are the average from 3 experiments.