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Summary of batch crystallization experiments
| Batch process – 1 | Batch process – 2 | Batch process – 3 | |
|---|---|---|---|
| Mode of crystallization | Reverse AS | Direct AS | AS split into two halves, first reverse with AS-1, followed by direct AS-2 addition |
| Temperature during addition of AS/saturated API (°C) | 45 | 45 | 65 |
| Cooling rate (°C/min) | 0.25 | 0.25 | 0.1 |
| Batch time (min) | 310 | 310 | 330 |
