Summary of the synthesis of propargylamine derivatives under metal-free conditions.

Reactants	Product	Catalyst	Solvent	Method employed	Reaction time	Yield	Limitations or progress	Ref.
		Nano-colloidal silica@APTPOSS	Toluene	Microwave irradiation, 50 °C	20–25 min	Up to 96%	(1) Efficient catalyst	Safaei-Ghomi et al.103
							(2) Recoverability of the catalyst.
							(3) Low catalyst loading
							(4) Short reaction times.
							(5) A simple procedure
							(6) High atom economy
		—	Solvent-free	80–90 °C	4–8 h	82–90%	(1) Metal-catalyst-free	Ghosh et al.104
							(2) Solvent-free conditions
		—	Magnetized water	MW, 60 °C	110–160 min	65–90%	(1) Simplicity	Bakherad et al.105
							(2) Low cost
							(3) Short reaction time
							(4) High reaction yield
							(5) Easy work-up
							(6) Absence of hazardous organic solvents
		—	DCM (play solvent and reactant role)	70 °C	12 h		(1) Simplicity of operation	Rawat et al.106
							(2) Mild conditions
							(3) High functional group tolerance