Table 1. Course of ADAMTS-13 activity, systemic lupus erythematosus autoantibodies, direct antiglobulin test, and MAIPA.
| 11.05.2011 | 13.04.2021 | 22.04.2021 | 28.04.2022 | 05.05.2021 | 12.05.2021 | 01.06.2021 | 01.07.2021 | 19.08.2021 | 09.09.2021 | 01.03.2022 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAMTS-13 activity (%; 50 – 110) | 2 | < 1 | < 1 | 4 | 28 | 32 | 39 | 62 | 82 | 99 | |
| ADAMTS-13 Ab (U/mL; < 16) | 31 | 40 | 56 | 16 | 8 | 15 | 8 | 7 | 5 | 5 | |
| ANA (titer) | 1 : 5,120 | 1 : 5,120 | 1 : 10,240 | 1 : 2,560 | 1 : 2,560 | 1 : 2,560 | 1 : 640 | ||||
| dsDNA Ab (ELISA; U/mL; < 20.0) | 189.8 | 189.3 | > 200 | 137.3 | 96.3 | 98.4 | 74.9 | ||||
| Coombs test (DAT) | |||||||||||
| Anti-IgG | + | +++ | – | ||||||||
| Anti-C3d | + | ++ | – | ||||||||
| Thrombocyte-specific Ab (MAIPA) | |||||||||||
| GP IIb/IIIa | + | + | – | ||||||||
| GP Ib/IX | – | + | – | ||||||||
| GP Ia/IIa | – | – | – | ||||||||
ADAMTS = A disintegrin and metalloprotease with thrombospondin-1-like domains; Ab = antibody; ANA = anti-nuclear antibody; dsDNA = double-stranded DNA; DAT = direct antiglobulin test; IgG = immunoglobulin G; C3d = complement 3d; MAIPA = monoclonal antibody immobilization of platelet antigens; GP = glycoprotein.