In vitro enzyme inhibition of compounds and antioxidant activity of compounds (1–15).
| Compound | Urease inhibition IC50 ± SDa | Antioxidant activity | |
|---|---|---|---|
| % Inhibition ± SDa | EC50 (μg ml−1) | ||
| 1 | 92.3 ± 0.20 | 71.1 ± 0.01 | 37.5 |
| 2 | 73.5 ± 0.65 | 43 ± 0.01 | — |
| 3 | 56.3 ± 0.78 | 67.4 ± 0.01 | 75 |
| 4 | 34.2 ± 0.72 | 29 ± 0.01 | — |
| 5 | NA | 12 ± 0.01 | — |
| 6 | NA | 71 ± 0.01 | 37.5 |
| 7 | NA | 57.8 ± 0.01 | 100 |
| 8 | 86.4 ± 0.78 | 32 ± 0.01 | — |
| 9 | 67.14 ± 0.67 | 57.8 ± 0.02 | 100 |
| 10 | NA | 57.9 ± 0.02 | 100 |
| 11 | 42.43 ± 0.65 | 71.1 ± 0.01 | 37.5 |
| 12 | NA | 43 ± 0.01 | — |
| 13 | NA | 57.7 ± 0.01 | 100 |
| 14 | NA | 23 ± 0.01 | — |
| 15 | NA | 69.3 ± 0.01 | 75 |
| Thiourea | 21.7 ± 0.12 | — | — |
| Acetohydroxamic acid | 37.0 | ||
| Ascorbic acid | — | 80 | 8.3 |
SD = standard deviation; NA = not applicable.