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(A) Prediction change in Glutamine (Q) of CDR3α from CAASFIIQGAQKLVF to CAASFIIQGA (*)KLVF, where (*) denotes a substituted amino acid position. (B) Prediction change in Valine (V) of CDR3α from CAASFIIQGAQKLVF to CAASFIIQGAQKL (*)F. (C) Prediction change in Tryptophan (W) of CDR3β from CASSLLGGWSEAFF to CASSLLGG (*)SEAFF. Notably, only Valine (V) of CDR3α has two H-bonds with the internal CDR3 alpha chain, and hence, altering it has the most substantial impact.
