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. 2023 May 12;13(11):1326–1345. doi: 10.1016/j.jpha.2023.05.002

Fig. 9.

Fig. 9

Fe-dihydromyricetin (DMY) nano-coordinated polymer particles (NCPs) regulate proteins associated with oxidative stress and endothelial dysfunction in rats. (A) Expression of DNA polymerase delta interacting protein 2 (Poldip2), recombinant nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4), vascular cell adhesion molecule-1 (VCAM-1), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF) in the retinas of different groups of rats by Western blot (WB) experiments. (B−F) Quantification of Poldip2 (B), Nox4 (C), VCAM-1 (D), HIF-1α (E), and VEGF (F) expression in the retinas of different groups of rats of WB experiments in Fig. 9A. (G−K) Expression of Poldip2 (G), Nox4 (H), VCAM-1 (I), HIF-1α (J), and VEGF (K) in the retinas of different groups of rats by enzyme-linked immunosorbent assay (ELISA) experiments. One-way analysis of variance (ANOVA), data represent mean ± standard error of mean (n = 5 per group). ∗ represented the significant difference between the administered (intervention) group and the DC group, and # represented the significant difference between the normal control (NC) group and the DC group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗/####P < 0.0001, compared with DC group. DC + Fe-DMY: DC group treated with high-dose Fe-DMY NCPs (60 mg/kg). Dose high: 60 mg/kg. Dose low: 10 mg/kg.