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. Author manuscript; available in PMC: 2024 Jan 2.
Published in final edited form as: Sci Signal. 2023 Sep 12;16(802):eabc9089. doi: 10.1126/scisignal.abc9089

Fig. 6. Fluoxetine inhibits passive systemic anaphylaxis.

Fig. 6.

(A) Mice were sensitized with anti-DNP IgE and treated with PBS or fluoxetine. The next day, anaphylaxis was induced with DNP-has and core body temperature was measured (A, N=9/group). (B) Mice were euthanized 30 minutes after DNP-HSA injection to assess plasma histamine levels by ELISA (N=10/group). (C) Mice were euthanized after 2 hours, and plasma was collected for cytokine analysis by ELISA (N=10/group). (D) Mice (N=5/group) were treated with PBS or fluoxetine as in (A). Histamine was administered and Core body temperature was measured. Data are pooled from two independent repeats. Statistical values were determined by 1-way ANOVA (Tukey’s test) and area under the curve and Student’s t-test in (A). *p<.05; **p<.001; ****p<.0001. n.s.=not statistically significant.