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. 2024 Jan 2;43:4. doi: 10.1186/s13046-023-02879-8

Fig. 1.

Fig. 1

Establishment of paclitaxel and gemcitabine resistant PDAC models. Graphical representation of the methodology used for generation of PR and GR models. B Growth curves of PR (upper panel) and GR (lower panel) cells, together with the parental cells, exposed to increasing concentrations of gemcitabine or paclitaxel. Sensitivity of PR cells to gemcitabine and GR cells to paclitaxel. B-Mean and SD of triplicates are shown. IC50 values were calculated as mean of 3 independent experiments, each performed in triplicate