Table 3.

Performance of F-CAD against WHO's Target Product Profile by reference

Reference		Xpert results	"abnormality suggestive of TB"	"any abnormality in the lung fields"
Sensitivity≧95	Actual sensitivity	0.954 (0.902–0.983)	0.951 (0.931–0.967)	0.950 (0.938–0.961)
	TB score	0.72	0.36	0.15
	Specificity (95%CI)	0.517 (0.488–0.545)	0.747 (0.737–0.757)	0.525 (0.513–0.537)
Sensitivity≧90	Actual sensitivity	0.900 (0.835–0.946)	0.901 (0.874–0.923)	0.900 (0.884–0.915)
	TB score	0.88	0.53	0.28
	Specificity (95%CI)	0.621 (0.594–0.648)	0.844 (0.835–0.852)*	0.750 (0.739–0.760)*
Specificity≧80	Actual specificity	0.800 (0.777–0.822)	0.800 (0.791–0.809)	0.800 (0.790–0.809)
	TB score	0.97	0.44	0.34
	Sensitivity (95%CI)	0.715 (0.630–0.791)	0.930 (0.907–0.949)	0.879 (0.862–0.895)
Specificity≧70	Actual specificity	0.700 (0.674–0.726)	0.700 (0.690–0.710)	0.700 (0.689–0.711)
	TB score	0.93	0.31	0.25
	Sensitivity (95%CI)	0.854 (0.854–0.910)	0.964 (0.946–0.977)*	0.914 (0.899–0.928)

*Significantly over Target Product Profile