Table 4.
VASARI features predicting IDH wildtype status resulted in 12 significant features with non-zero coefficients
| Selected VASARI features | Logistic LASSO coefficient | Category | OR (95% CI) | p-value |
|---|---|---|---|---|
| f1–tumor location | 0.199 | |||
| f3–eloquent brain | 0.106 | |||
| f5–proportion enhancing | 0.240 | (34–67%) | 6.333 (1.854—21.638) | 0.003 |
| f6–proportion of non-enhancing | -0.214 | |||
| f10–T1/FLAIR ratio | 0.276 | (infiltrative) | 4.727 (1.587—14.074) | 0.005 |
| f11–thickness of enhancing margin | 0.377 | (thick/nodular) | 6.328 (1.880—21.295) | 0.003 |
| f13–definition of the non-enhancing margin | -0.224 | |||
| f22–non-contrast enhancing crosses midline | -0.191 | |||
| f23–contrast-enhancing crosses midline | -1.077 | |||
| f24–satellites | 0.037 | |||
| f29–longest diameter | -0.142 | |||
| f30–perpendicular to longest diameter | -0.143 |
Categories (within parentheses) have significant odds ratios compared to their base categories for predicting IDH wildtype status
VASARI Visually AcceSAble Rembrandt Images, OR odds ratio, FLAIR fluid-attenuated inversion recovery, LASSO (Least Absolute Shrinkage and Selection Operator), IDH Isocitrate dehydrogenase