Table 5.

VASARI features predicting MGMT unmethylated status resulted in 5 significant features with non-zero coefficients

Selected VASARI features	Logistic LASSO coefficients	Category	OR (95% CI)	p-value
f6–proportion of non-enhancing	-0.176	(68–100%)	0.215 (0.067—0.687)	0.009
f13–definition of the non-enhancing margin	-0.019
f15–edema crosses midline	-0.351	(yes)	0.305 (0.125—0.742)	0.009
f25–calvarial modeling	-0.399
f29–longest diameter	-0.084		0.746 (0.599—0.929)	0.009

Categories (within parentheses) have significant odds ratios compared to their base categories for predicting MGMT unmethylated status

VASARI Visually AcceSAble Rembrandt Images, OR odds ratio, LASSO (Least Absolute Shrinkage and Selection Operator), MGMT Methylguanine-DNA-methyltransferase