Comparison 2. Combined Androgen Blockade with Flutamide.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Survival 1 year	9	4119	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.76, 1.25]
1.1 CAB with flutamide versus orchiectomy	4	2171	Odds Ratio (M‐H, Random, 95% CI)	0.91 [0.60, 1.39]
1.2 CAB with flutamide versus LHRHa	5	1948	Odds Ratio (M‐H, Random, 95% CI)	1.02 [0.72, 1.43]
2 Survival: 2 year	9	4028	Odds Ratio (M‐H, Random, 95% CI)	1.09 [0.90, 1.31]
2.1 CAB with flutamide versus orchiectomy	4	2163	Odds Ratio (M‐H, Random, 95% CI)	0.90 [0.65, 1.24]
2.2 CAB with flutamide versus LHRHa	5	1865	Odds Ratio (M‐H, Random, 95% CI)	1.30 [1.07, 1.58]
3 Survival: 5 year	6	3216	Odds Ratio (M‐H, Random, 95% CI)	1.26 [1.08, 1.47]
3.1 CAB with flutamide versus orchiectomy	3	1803	Odds Ratio (M‐H, Random, 95% CI)	1.21 [0.98, 1.49]
3.2 CAB with flutamide versus LHRHa	3	1413	Odds Ratio (M‐H, Random, 95% CI)	1.32 [1.04, 1.68]