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[Preprint]. 2023 Dec 12:2023.12.12.570420. [Version 1] doi: 10.1101/2023.12.12.570420

Figure 3. miR153 overexpression impacts GABAergic synaptic transmission.

Figure 3.

(A) Representative mIPSC current traces from miRCon and miR153 OE-expressing neurons in hippocampal culture.

(B) Quantification of mIPSC frequency (left) and amplitude (right) from miRCon and miR153 OE-expressing neurons. n = 17–19 neurons per condition.

(C) Cumulative frequency distribution of mIPSC inter-event intervals (IEI) for events in miRCon and miR153 OE-expressing neurons.

(D) Cumulative frequency distribution of mIPSC amplitude for events in miRCon and miR153 OE-expressing neurons.

(E) Representative traces recorded from miRCon and miR153 OE-expressing neurons in acute hippocampal slices.

(F) Quantification of mIPSC frequency (left) and amplitude (right) from miRCon and miR153 OE-expressing neurons. n = 17–22 neurons per condition.

(G) Cumulative frequency distribution of mIPSC IEI for events in miRCon and miR153 OE-expressing neurons.

(H) Cumulative frequency distribution of mIPSC amplitude for events in miRCon and miR153 OE-expressing neurons.

All values represent mean ± SEM. *p<0.05 and **p<0.01, ***p<0.005, ****p<0.0001; Mann-Whitney test.