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A schematic diagram of BCG-disA-OE’s intra-cellular delivery of cyclic di-nucleotides (CDNs) and subsequent binding to the STING homodimer; STING-CDN trafficking to the Golgi via ER-Golgi intermediate compartment (ERGIC) and then TBK-1 recruitment and subsequent phosphorylation of IRF3 and NFκβ for downstream transcriptional activation of pro-inflammatory cytokines.
