Figure 2. The kinetics and antigenic landscape of S2-directed mAbs.

(A) A phylogenetic tree based on the heavy chain of each mAb is shown, with the indicated features of each mAb displayed below. (B) Pair-wise competition analysis was used to map the epitope community for a sub-set of S2-DS5 reactive mAbs. Circles indicate individual mAbs with larger clusters grouped together and colored by community. Solid lines connecting mAbs indicate that the two antibodies compete bi-directionally; dotted lines indicate asymmetric competition.