Table 1:
Top 50 proteins reduced (40 by ≥ 2-fold) after one-week CHIR99021 treatment of ARPE-19 cells.
| accession # | gene name | description | fold change vs. DMSO |
|---|---|---|---|
| P20908 | COL5A1 | Collagen alpha-1(V) chain | 0.073 |
| P29279 | CCN2 | CCN family member 2 | 0.142 |
| P31689 | DNAJA1 | DnaJ homolog subfamily A member 1 | 0.179 |
| Q01105 | SET | Protein SET | 0.186 |
| P08253 | MMP2 | 72 kDa type IV collagenase | 0.248 |
| Q14767 | LTBP2 | Latent-transforming growth factor beta-binding protein 2 | 0.253 |
| P05121 | SERPINE1 | Plasminogen activator inhibitor 1 | 0.259 |
| P23352 | ANOS1 | Anosmin-1 | 0.267 |
| P21589 | NT5E | 5'-nucleotidase | 0.281 |
| Q96DG6 | CMBL | Carboxymethylenebutenolidase homolog | 0.289 |
| P55145 | MANF | Mesencephalic astrocyte-derived neurotrophic factor | 0.298 |
| Q9HBR0 | SLC38A10 | Putative sodium-coupled neutral amino acid transporter 10 | 0.322 |
| P28300 | LOX | Protein-lysine 6-oxidase | 0.326 |
| O00622 | CCN1 | CCN family member 1 | 0.328 |
| P08572 | COL4A2 | Collagen alpha-2(IV) chain | 0.331 |
| P11233 | RALA | Ras-related protein Ral-A | 0.349 |
| P09429 | HMGB1 | High mobility group protein B1 | 0.368 |
| P06702 | S100A9 | Protein S100-A9 | 0.372 |
| P46108 | CRK | Adapter molecule crk | 0.390 |
| P02462 | COL4A1 | Collagen alpha-1(IV) chain | 0.391 |
| Q96IZ0 | PAWR | PRKC apoptosis WT1 | 0.395 |
| Q15582 | TGFBI | Transforming growth factor-beta-induced protein | 0.400 |
| Q9UKM7 | MAN1B1 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | 0.405 |
| O94819 | KBTBD11 | Kelch repeat and BTB domain-containing protein 11 | 0.413 |
| P06454 | PTMA | Prothymosin alpha | 0.414 |
| Q562R1 | ACTBL2 | Beta-actin-like protein 2 | 0.450 |
| P12036 | NEFH | Neurofilament heavy polypeptide | 0.459 |
| Q01955 | COL4A3 | Collagen alpha-3(IV) chain | 0.463 |
| P23142 | FBLN1 | Fibulin-1 | 0.465 |
| P67775 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.468 |
| O75095 | MEGF6 | Multiple epidermal growth factor-like domains protein 6 | 0.471 |
| Q92599 | SEPTIN8 | Septin-8 | 0.476 |
| P17980 | PSMC3 | 26S proteasome regulatory subunit 6A | 0.477 |
| P98095 | FBLN2 | Fibulin-2 | 0.484 |
| Q15147 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | 0.487 |
| P20827 | EFNA1 | Ephrin-A1 | 0.491 |
| O43184 | ADAM12 | Disintegrin and metalloproteinase domain-containing protein 12 | 0.492 |
| P98160 | HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein | 0.494 |
| P01024 | C3 | Complement C3 | 0.497 |
| P05387 | RPLP2 | 60S acidic ribosomal protein P2 | 0.499 |
| Q86XX4 | FRAS1 | Extracellular matrix organizing protein FRAS1 | 0.502 |
| P62993 | GRB2 | Growth factor receptor-bound protein 2 | 0.502 |
| P05386 | RPLP1 | 60S acidic ribosomal protein P1 | 0.519 |
| Q6YP21 | KYAT3 | Kynurenine--oxoglutarate transaminase 3 | 0.524 |
| Q9UNH7 | SNX6 | Sorting nexin-6 | 0.525 |
| P78344 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | 0.526 |
| Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | 0.527 |
| O43405 | COCH | Cochlin | 0.529 |
| P26583 | HMGB2 | High mobility group protein B2 | 0.532 |
| P07996 | THBS1 | Thrombospondin-1 | 0.532 |