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[Preprint]. 2023 Dec 15:2023.12.14.571662. [Version 1] doi: 10.1101/2023.12.14.571662

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Figure 1: — (a) Cartoon of steps in ClpXP degradation of a protein substrate. (b) Overlay of cryo-EM map and model of ClpXP bound to the degron-tagged DHFR substrate (left). Density for the degron tail could be modeled extending from the folded domain of DHFR to the ClpP entry portal (center). The insets (right) display density for methotrexate and the DHFR Trp³⁰ and Phe³¹ side chains (top), and the last two residues of native DHFR, Arg¹⁵⁸, and Arg¹⁵⁹, contacted by the pore-1 loop of ClpX subunit A, which includes Tyr¹⁵³.